Tetrahydroquinazolin-4(3h)-one-related and...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 471/04 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 239/91 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2572084

Compounds are provided having the formula (I) wherein variables A1, A2, A3, A4, R1, R2, R3, R4, Q and L are described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

La présente invention concerne des composés représentés par la formule (I) dans laquelle les variables A1, A2, A3, A4, R1, R2, R3, R4, Q et L sont telles que décrites dans les spécifications. Ces composés conviennent particulièrement au traitement d'états et affections de nature inflammatoires et immunitaires. L'invention concerne également des compositions et des procédés convenant à des traitements utilisant les composés de l'invention. Les pathologies concernées sont essentiellement la sclérose en plaque, la polyarthrite rhumatoïde, le psoriasis et l'inflammation intestinale.

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