Tetrahydroquinoline analogues as muscarinic agonists

Details Tetrahydroquinoline analogues as muscarinic agonists Tetrahydroquinoline analogues as muscarinic agonists

C - Chemistry, Metallurgy

07

D

C07D 417/06 (2006.01) A61K 31/435 (2006.01) A61P 43/00 (2006.01) C07D 221/00 (2006.01) C07D 279/00 (2006.01) C07D 401/04 (2006.01) C07D 413/06 (2006.01) C07D 451/02 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2470578

The present invention relates to tetrahydroquinoline compounds as formulas I, as well as salts and isomers thereof wherein m is 0, 1 or 2; C3-C4is CH2-CH or CH=Cor C4 is CH and C3 is absent; L1 and L2 are biradicals independently selected from the group consisting of -C(R6)=C(R7), -C(R6)=N, -N=C(R6)-, -S-, - NH- and -O-; wherein only one of L1 and L2 may be selected from the group consisting of -S-, NH - and O; Y is selected from the group consisting of O, S, and H2; X is a biradical as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.

La présente invention porte sur des composés de tétrahydroquinoline utiles comme agonistes des récepteurs muscariniques; sur des compositions les comprenant; sur des procédés visant à inhiber une activité d'un récepteur muscarinique avec ces composés; sur des procédés de traitement au moyen de ces composés d'un état pathologique associé à un récepteur muscarinique; et sur des procédés d'identification d'un sujet apte à subir un traitement au moyen de ces composés.

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