Tetrahydroquinoline derivatives and a process for preparing...

Details Tetrahydroquinoline derivatives and a process for preparing... Tetrahydroquinoline derivatives and a process for preparing...

C - Chemistry, Metallurgy

07

D

C07D 491/04 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/4545 (2006.01) A61K 31/47 (2006.01) A61P 3/06 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2560402

A novel compound of the formula (I): (see formula I) wherein R1 is alkoxycarbonyl or the like, R2 is alkyl or the like; R3 is hydrogen or the like; R4 is alkylene or the like; R5 is optionally substituted heterocyclic group; R6, R7, R8 and R9 are independently hydrogen; alkyl, alkoxy, or the like; R10 is optionally substituted aromatic ring, or the like; or a pharmaceutically acceptable salt thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP).

Il est prévu un nouveau composé de la formule (I) : où R1 est un alkoxy carbonyle ou autre, R2 est un alkyle ou autre ; R3 est un hydrogène ou autre ; R4 est un alkylène ou autre ; R5 est un groupe hétérocyclique substitué en option ; R6, R7, R8 et R9 sont indépendamment de l'hydrogène ; un alkyle, un alkoxy, ou autre ; R10 est un anneau aromatique substitué en option, ou autre ; ou un sel acceptable pharmaceutiquement de celui-ci, ayant une activité inhibitoire contre la protéine de transfert d~ester cholestéryle (CETP).

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