Tetrahydroquinoline derivatives useful for neurodegenerative...

Details Tetrahydroquinoline derivatives useful for neurodegenerative... Tetrahydroquinoline derivatives useful for neurodegenerative...

C - Chemistry, Metallurgy

07

D

167/226, 260/277

C07D 215/02 (2006.01) A61K 31/47 (2006.01) C07D 215/48 (2006.01) C07D 215/50 (2006.01) C07D 401/02 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 405/02 (2006.01) C07D 405/04 (2006.01) C07D 409/02 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2011686

T1050Y ABSTRACT TETRHYDROQUINOLINE DERIVATIVES USEFUL FOR NEURODEGENERATIVE DISORDERS A class of 1,2,3,4-tetrahydroquinolines possessing at least one substituent, or a spirocyclic moiety, at the 4-position, and an acidic group or a group convertible thereto in vivo at the 2-position, are specific antagonists of N-methyl-D-aspartate (NMDA) receptors and are therefore useful in the treatment and/or prevention of neurodegenerative disorders.

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