Tetrahydroquinolines and their use as modulators of...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 215/00 (2006.01) A61K 31/4709 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2610873

The invention relates to ethynyl-substituted tetrahydroquinolinone derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are group I mGluR modulators and are therefore useful for the control and prevention of acute and/or chronic neurological disorders.

La présente invention a trait à des dérivés de tétrahydroquinolinone ainsi qu~à leurs sels pharmaceutiquement acceptables. L~invention concerne aussi un procédé de préparation de tels composés. Les composés de cette invention sont des modulateurs de groupe I mGluR et sont par conséquent utiles pour le contrôle et la prévention de désordres neurologiques aigus et/ou chroniques.

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