Tetrahydrothiophene derivatives

Details Tetrahydrothiophene derivatives Tetrahydrothiophene derivatives

C - Chemistry, Metallurgy

07

D

C07D 333/38 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) C07D 409/12 (2006.01) C07D 495/08 (2006.01)

Patent

CA 2090548

ABSTRACT OF THE DISCLOSURE A compound of the formula [I] and pharmaceutically acceptable salts thereof; and a synthetic intermediate represented by the formula [II] and pharmaceutically acceptable salts thereof, Image [I] Image [II] wherein R 1 is hydrogen or lower alkyl; R 2 is hydrogen or a protective group of thiol; R 3 is hydroxy, a remainder of ester group or a remainder of amido group; A is straight or branched lower alkylene, and the sulfur atom in the side chain may be directly join with -CO- to conform a thiolactone ring. The compounds of this invention have excellent thymulin-like activities and are expected to be useful for treatment of various immune disorders such as immunodeficiency and autoimmune diseases.

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