C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 333/38 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) C07D 409/12 (2006.01) C07D 495/08 (2006.01)
Patent
CA 2090548
ABSTRACT OF THE DISCLOSURE A compound of the formula [I] and pharmaceutically acceptable salts thereof; and a synthetic intermediate represented by the formula [II] and pharmaceutically acceptable salts thereof, Image [I] Image [II] wherein R 1 is hydrogen or lower alkyl; R 2 is hydrogen or a protective group of thiol; R 3 is hydroxy, a remainder of ester group or a remainder of amido group; A is straight or branched lower alkylene, and the sulfur atom in the side chain may be directly join with -CO- to conform a thiolactone ring. The compounds of this invention have excellent thymulin-like activities and are expected to be useful for treatment of various immune disorders such as immunodeficiency and autoimmune diseases.
Kato Nobuharu
Kawashima Yoichi
Mita Shiro
Morishita Masataka
Suhara Hiroshi
Fetherstonhaugh & Co.
Santen Pharmaceutical Co. Ltd.
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