Tetralin and indane derivatives and uses thereof

Details Tetralin and indane derivatives and uses thereof Tetralin and indane derivatives and uses thereof

C - Chemistry, Metallurgy

07

D

C07D 295/08 (2006.01) A61K 31/4995 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2591793

Compounds of the formula (I) or pharmaceutically acceptable salts thereof, wherein R2 is a group of formula (II) and m, n, p, q, r, Rl and X are as defined in the claims, which are selective agonists of 5-HT6 and 5-HT2A. Also provided are compositions comprising these compounds and methods for their use in the preparation of medicaments for treating central nervous system disease states and disorders of the gastrointestinal tract.

L'invention concerne les composés représentés par la formule (I),ou des sels pharmaceutiquement acceptables de ceux-ci. R2 représente un groupe de formule (II), et m, p, q, Ar, Rl et X sont tels que définis dans les revendications. Ces composés sont des agonistes sélectifs de 5-HT6 et de 5-HT2A. L'invention concerne également des compositions contenant ces composés, ainsi que des procédés d'utilisation de ceux-ci pour la préparation de médicaments destinés à traiter les états pathologiques du système nerveux central, et les affections du tractus gastro-intestinal.

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