Tetralone-based monoamine reuptake inhibitors

Details Tetralone-based monoamine reuptake inhibitors Tetralone-based monoamine reuptake inhibitors

C - Chemistry, Metallurgy

07

C

C07C 211/30 (2006.01) A61K 31/135 (2006.01) C07C 211/42 (2006.01)

Patent

CA 2636275

The invention relates to novel tetralone based amines and their use in the treatment of central nervous system (CNS) disorders, such as depression, attention deficit hyperactivity disorder (ADHD) and Parkinson's disease. The invention further relates to pharmaceutical compositions containing the compounds and compositions of the invention as well as methods of inhibiting reuptake of one or more monoamine, such as such as dopamine and norepinephrine, from the synaptic cleft, and methods of modulating one or more monoamine transporter.

L'invention concerne de nouvelles amines à base de tétralone et leur utilisation dans le traitement des troubles du système nerveux central (SNC), tels que la dépression, l'hyperactivité avec déficit de l'attention (ADHD) et la maladie de Parkinson. L'invention concerne également des compositions pharmaceutiques contenant les composés et les compositions de l'invention, ainsi que des procédés d'inhibition du recaptage d'une ou de plusieurs monoamines, telles que la dopamine et la norépinéphrine, dans la fente synaptique, et des procédés de modulation d'un ou de plusieurs transporteurs de monoamine.

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