Tetraoxo compounds

Details Tetraoxo compounds Tetraoxo compounds

C - Chemistry, Metallurgy

07

D

167/211, 260/263

C07D 471/08 (2006.01) A61K 31/445 (2006.01) C07D 471/10 (2006.01)

Patent

CA 1272196

ABSTRACT OF THE DISCLOSURE Tetraoxo compounds of the Formula (I) Image (I) wherein R1 is an alkyl, alkenyl, phenylalkyl or cycloalkylalkyl group, R2 and R3 are each independently an alkyl or phenyl group or together denote an alkylene group, W is a (CH2)n-Q group, in which n is 2 to 10 and Q is a) a displaceable leaving group X, or b) Z-R4, where Z is a 1-piperazinyl group, and R4 is in position 4, and is hydrogen or a phenyl, substituted phenyl, N-heteroaryl or substituted N-heteroaryl group; and salts and acid addition salts of said compound, and a method for their preparation. Selected compounds of Formula (I) have been found to have central nervous system affecting activity.

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