Tetrapeptide derivative crystals

Details Tetrapeptide derivative crystals Tetrapeptide derivative crystals

C - Chemistry, Metallurgy

07

K

C07K 5/10 (2006.01) A61K 9/08 (2006.01) A61K 31/40 (2006.01) A61K 38/07 (2006.01) A61P 35/00 (2006.01) C07D 207/09 (2006.01) C07K 5/02 (2006.01) C07K 5/103 (2006.01) C30B 29/54 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2460956

The invention provides crystals of N2-(N,N-dimethyl-L-valyl)- N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo- 3-[(2-phenylethyl)aminolpropyl]-1-pyrrolidinyl]-1-[(S)-1-methylpropyl ]- 4-oxobutyl]-N-methyl-L-valinamide or salts thereof which possess potent antitumor activity and methods for their preparation.

L'invention concerne des cristaux d'un dérivé de tétrapeptide N?2¿-(N, N- diméthyl-L-valyl)-N-[(1S,2R)-2-méthoxy-4-[(2S)-2-[(1R,2R)-1-méthoxy-2-méthyl-3-oxo-[(2-phényléthyl)amino]propyl]-1-pyrolidinyl]-1-[(S)-1-méthylpropyl]-4-oxobutyl]-N-méthyl-L-valinamide doté d'un effet antinéoplasique puissant ou le sel associé, et son procédé d'élaboration.

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