Tetrapeptide stimulating functional activity of neurones,...

Details Tetrapeptide stimulating functional activity of neurones,... Tetrapeptide stimulating functional activity of neurones,...

C - Chemistry, Metallurgy

07

K

C07K 5/10 (2006.01) A61K 38/07 (2006.01) A61P 25/00 (2006.01) C07K 5/103 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2388357

Tetrapeptide L-alanyl-L-glutamyl-L-asparagyl-L-proline of the general formula L-Ala-L-Glu-Asp-L-Pro is proposed as a biologically active compound stimulating the functional activity of neurones. The application of L-Ala-L- Glu-L-Asp-L-Pro tetrapeptide in medicine is proposed for the preparation of a drug stimulating the functional activity of neurones. There is proposed a pharmacological agent, which contains as its active base an effective amount of L-Ala-L-Glu-L-Asp-L-Pro tetrapeptide or its salts of the amino acid group (acetate, hydrochloride, oxalate) or its slats of carboxyl groups (the salts of sodium, potassium, calcium, lithium, zinc, magnesium, and also the salts of organic and inorganic cations-ammonium, triethylammonium). The agent is proposed for parenteral, intranasal and oral administration. In accordance with the invention, the method of stimulating the functional activity of neurones consists in preventive and/or therapeutic administration to the patient of the pharmacological agent in doses 0.01 to 100 µg/kg of the body weight at least once a day for a period necessary for attaining a therapeutic effect.

Selon l'invention, on propose le tétrapeptide L-alanyl-L-glutamyl-L-aspartyl-L-proline ayant la formule générale L-Ala-L-Glu-Asp-L-Pro en tant que composant bioactif qui stimule l'activité fonctionnelle des neurones. On propose d'appliquer le tétrapeptide L-Ala-L-Glu-L-Asp-L-Pro en médecine, pour préparer un médicament stimulant l'activité fonctionnelle des neurones. L'invention propose un agent pharmacologique dont le principe actif est constitué par une quantité efficace du tétrapeptide L-Ala-L-Glu-L-Asp-L-Pro ou de ses sels du groupe d'acides aminés (acétate, hydrochloride, oxalate) ou de ses sels du groupe carboxyle (sels de sodium, potassium, calcium, lithium, zinc, magnésium et sels de cations organiques et inorganiques, à savoir d'ammonium et de triéthylammonium). L'agent est proposé pour l'administration parentérale, intranasale et orale. Selon l'invention, le procédé de stimulation de l'activité fonctionnelle des neurones consiste à administrer au patient de façon préventive et/ou thérapeutique l'agent pharmacologique dans des doses entre 0,01 et 100 µg/kg du poids corporel au moins une fois par jour, et ce pour atteindre l'effet thérapeutique désiré.

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