C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/7.06, 530/5.
C07K 5/103 (2006.01) C07K 5/113 (2006.01) C07K 7/06 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1120031
ORTH 333 ABSTRACT NEW TETRAPEPTIDES AND METHODS There are disclosed new biologically active polypeptides containing the following polypeptide seg- ment: -ALA-LYS-SER-GLN-. Biological activity is generally retained upon substi- tution of a natural or non-natural amino acid residue for either or both of L-alanyl in the first position and L-seryl in the third position. These polypeptides have the capability of in- ducing the differentiation of T-lymphocytes as measured by the acquisition of the thymic differentiation antigen Th-1, as well as B-lymphocytes as measured by the acquisi- tion of the differentiation antigen Bu-1. The polypeptides are thus useful in thymic function and immunity areas such as in treatment for congenital absence of thymus. Also provided are substituted polypeptides, methods of manu- facture of the polypeptides, therapeutic compositions, and methods for use of the polypeptides.
317547
Gowling Lafleur Henderson Llp
Ortho Pharmaceutical Corporation
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