Tetraspan protein and uses thereof

Details Tetraspan protein and uses thereof Tetraspan protein and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/11 (2006.01) C12N 15/66 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2415690

Inhibitors of TSPAN-7 are provided that reduce the expression or biological activities of TSPAN-7 in a mammalian cell. TSPAN-7 inhibitors include antisense molecules, ribozymes, antibodies and antibody fragments, proteins and polypeptides as well as small molecules. TSPAN-7 inhibitors find use in compositions and methods for decreasing TSPAN-7 gene expression as well as methods for inhibiting proliferation of mammalian cells, including tumor cells, methods for decreasing the side effects of cancer therapy and methods for treating neoplastic diseases. Also provided are nucleic acids encoding a new member of the tetraspan family, TSPAN-7, and polypeptides encoded thereby.

L'invention concerne des inhibiteurs de Tétraspan-7 (TSPAN-7) qui permettent de diminuer l'expression ou les activités biologiques de TSPAN-7 dans une cellule mammifère. Ces inhibiteurs de TSPAN-7 comprennent des molécules antisens, des ribozymes, des anticorps et des fragments d'anticorps, des protéines et des polypeptides ainsi que des petites molécules. Les inhibiteurs de TSPAN-7 sont employés dans des compositions et des procédés servant à diminuer l'expression du gène TSPAN-7, dans des méthodes d'inhibition de la prolifération de cellules mammifères, et notamment de cellules tumorales, dans des méthodes de réduction des effets secondaires d'une thérapie anticancéreuse et dans des méthodes de traitement des maladies néoplasiques. L'invention concerne également des acides nucléiques codant un nouveau membre de la famille tétraspan, TSPAN-7, et des polypeptides codés par ces acides.

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