Tetrazole-5-carboxamide derivatives

Details Tetrazole-5-carboxamide derivatives Tetrazole-5-carboxamide derivatives

C - Chemistry, Metallurgy

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D

260/312, 260/289

C07D 257/04 (2006.01) A61K 31/41 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 213/75 (2006.01) C07D 247/00 (2006.01) C07D 277/46 (2006.01) C07D 295/12 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 1086729

Abstract of the Disclosure Anti-allergic agents of N-aromatic 1H-(or 2H)tetrazole-5-carboxamide derivation present the following structural formula: Image in which R1 is -CN or -CONH2 R2 is lower alkoxy, hydroxy(lower)alkoxy, or Image wherein R7 and R8 are independently hydrogen, lower alkyl, or cycloalkyl of 5 to 6 carbon atoms, or R7 and R8, when taken together with the nitrogen atom to which they are attached form a heterocyclic group selected from aziridiayl, azetidinyl, pyrrolidinyl, piperidino, pipera- zinyl, 4-lower alkyl piperazinyl, morpholino, thiomorpholino and ring substituted lower alkyl analogues of said heterocyclic groups; R3 is hydrogen, lower alkyl, lower alkoxy\, halo, polyhalo(lower)alkyl, lower alkyl- carbonyl or carb(lower)alkoxy; or a pharmaceutically acceptable salt thereof.

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