Tetrazole diphenoxy (thio) alkylene derivatives

Details Tetrazole diphenoxy (thio) alkylene derivatives Tetrazole diphenoxy (thio) alkylene derivatives

C - Chemistry, Metallurgy

07

D

260/312, 260/559

C07D 257/04 (2006.01) C07C 149/415 (1985.01) C07C 161/02 (1985.01)

Patent

CA 1202632

ABSTRACT OF THE INVENTION ORGANIC COMPOUNDS AND THEIR PHARMACEUTICAL USE There are described compounds of the formula Image (I) in which R1 is hydrogen or C1-6alkyl, R2 is hydrogen, C1-6alkyl or C3-6alkenyl, X and Y are each oxygen, sulphur, sulphinyl or sulphonyl, n is 2 to 6 and Z is 1H-tetrazol-5-yl, 1H-tetrazol-5- ylthio, 1H-tetrazol-5-ylsulphinyl, 1H-tetrazol-5-ylsulphonyl, cyano or thiocyano, provided that when both X and Y are oxygen Z is 1H-tetrazol-5-ylthio, 1H-tetrazol-5-ylsulphinyl, 1H-tetrazol-5- ylsulphonyl or thiocyano; and salts thereof. The compounds in which Z is other than cyano or thiocyano have pharmaceutical activity and inhibit leukotriene action or formation.

439422

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