Tetrazole pharmaceutical derivatives

Details Tetrazole pharmaceutical derivatives Tetrazole pharmaceutical derivatives

C - Chemistry, Metallurgy

07

D

260/312, 260/454

C07D 257/04 (2006.01) C07C 45/71 (2006.01) C07C 49/84 (2006.01) C07C 331/10 (2006.01)

Patent

CA 1222517

ABSTRACT OF THE INVENTION NOVEL TETRAZOLE PHARMACEUTICAL DERIVATIVES Compound of formula Image (I) wherein R1, R2 and R3 are each independently selected from H, OH, C1-C4alkyl, R4-CO and halogen, where R4 is C1-C4alkyl; R5 and R6 are each independently selected from H, C1-C4alkyl and optionally-substituted phenyl; R7 is an alkylene group having from 1 to 4 carbon atoms, optionally containing a substituted or unsubstituted phenyl group; p is 0 or 1; and Z is a 1H-tetrazol- 5-yl or a -CN group; and salts thereof, may be prepared by reacting a compound of formula. Image with a compound of formula Image wherein R1-R7 are as previously defined, in an organic solvent at a temperature in the range of 40 - 120°C in the presence of a base, and reacting the resulting compound with an alkali metal cyanide or thiocyanate, and optionally reacting the resulting compound with a source of azide ions to produce pharmacologically active compounds of formula I wherein Z is lH-tetrazol-5-yl.

458592

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