Texture masked particles containing an active ingredient

Details Texture masked particles containing an active ingredient Texture masked particles containing an active ingredient

A - Human Necessities

61

K

A61K 45/08 (2006.01) A61K 9/00 (2006.01) A61K 9/32 (2006.01) A61K 9/50 (2006.01) A61K 9/68 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2365844

Texture masked particles and chewable tablets made therefrom are disclosed. The texture masked particles are comprised of a core containing an active ingredient, an optional first coating layer comprised of a taste masking agent that substantially covers the core; and a second coating layer, which optionally may substantially cover the first coating layer or the core, comprised of a film forming polymer and a anti-grit agent. The particles may be produced into a tablet form, such as a chewable tablet form, that provides for the immediate release of the active ingredient.

L'invention porte sur des particules dont la texture est masquée et des comprimés à croquer fabriquées avec celles-ci. Les particules dont la texture est masquée sont constituées d'un noyau contenant un ingrédient actif, une première couche d'enrobage facultative comprenant un agent masquant le goût qui couvre considérablement le noyau et d'une deuxième couche d'enrobage, qui peut facultativement couvrir en grande partie la première couche d'enrobage ou le noyau, laquelle est composée d'un polymère formant une pellicule et d'un agent prévenant la formation de petits grains. Les particules peuvent être manipulées pour donner un comprimé, comme les comprimés à croquer, qui permet la libération immédiate de l'ingrédient actif.

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