Tfg-beta induced gene family

Details Tfg-beta induced gene family Tfg-beta induced gene family

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2059596

-29- ABSTRACT OF THE DISCLOSURE A new gene family induced by TGF-beta is disclosed. Two new genes, designated .beta.IG-M1 and .beta.IG-M2, are induced in response to TGF-B1 treatment of mouse embryo fibroblasts. These genes encode proteins containing about 345 to about 380 amino acid residues, with a molecular weight of about 37,000 to about 48,000daltons and about 38 cysteine residues. The induced proteins share about 50 % homology with each other and significant homology with a v-src induced protein in chicken embryo fibroblasts designated CEF-10. These proteins may be involved in producing some of the growth and differention modulating effects of TGF-.beta.1.

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