Tgf-.alpha. polypeptides, functional fragments and methods...

Details Tgf-.alpha. polypeptides, functional fragments and methods... Tgf-.alpha. polypeptides, functional fragments and methods...

C - Chemistry, Metallurgy

07

K

C07K 14/495 (2006.01) A61K 38/03 (2006.01) A61P 1/00 (2006.01) A61P 3/04 (2006.01) A61P 25/28 (2006.01) C07K 7/00 (2006.01)

Patent

CA 2371241

Disclosed are peptides related to human TGF-.alpha., having TGF-.alpha. biological activity, which are useful for many of the indications that full- length TGF-.alpha. polypeptide is useful. Also provided are methods of use of such peptides, as well as human TGF-.alpha. and biologically related polypeptides. For example, methods for treating or preventing cachexia in subjects are provided as well as methods for stimulating hematopoiesis in patients undergoing cytotoxic chemotherapy. In addition, the use of TGF- .alpha. related peptides to related neurode generative diseases is also provided. Methods of the invention also provide protection for patients undergoing cytotoxic therapy from side effects such as gastrointestinal (GI) mucositis.

L'invention concerne des peptides associés au TGF-.alpha. humain, présentant une activité biologique TGF-.alpha., utiles dans bien des indications pour lesquelles le TGF-.alpha. pleine longueur est préconisé. L'invention porte également sur des procédés d'utilisation de ces peptides ainsi que sur le TGF-.alpha. humain et ses polypeptides biologiquement associés. L'invention concerne notamment des méthodes de traitement ou de prévention de la cachexie ainsi que des méthodes de stimulation de l'hématopoïèse chez des sujets soumis à une chimiothérapie cytotoxique. En outre, l'invention porte sur l'utilisation de peptides associés au TGF-.alpha. humain pour des maladies neurodégénératives associées. Des méthodes de l'invention traitent également de la protection des patients soumis à une thérapie cytotoxique, contre les effets secondaires tels que la mucosite gastro-intestinale.

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