A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) C07K 1/00 (2006.01) C07K 14/495 (2006.01)
Patent
CA 2380635
Disclosed are TGF-.alpha. polypeptides, related polypeptides, fragments and mimetics thereof useful in stimulating stem cell or precursor cell proliferation, migration and differentiation. The methods of the invention are useful to treat tissue injury as well as expand stem cell populations in, or obtained from, gastrointestinal, musculoskeletal, urogenital, neurological and cardiovascular tissues. The methods include ex vivo and in vivo applications.
L'invention porte sur des polypeptides TGF-.alpha., sur des polypeptides apparentés, des fragments et des imitations de ceux-ci utilisés dans la stimulation de la prolifération, la migration et la différenciation des cellules souches ou cellules précurseurs. Les procédés de cette invention sont utiles pour traiter des lésions tissulaires ainsi que des populations étendues de cellules souches dans ou obtenues à partir des tissus gastro-intestinaux, musculosquelettiques, génito-urinaires, neurologiques et cardio-vasculaires. Ces procédés incluent des applications ex vivo et in vivo.
Felker Thomas S.
Paskell Stefan
Pernet Andre
Twardzik Daniel R.
Applied Protein Sciences Llc
Mbm Intellectual Property Law Llp
Stem Cell Pharmaceuticals Inc.
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