Tgf-beta 1/beta 2: a novel chimeric transforming growth...

Details Tgf-beta 1/beta 2: a novel chimeric transforming growth... Tgf-beta 1/beta 2: a novel chimeric transforming growth...

C - Chemistry, Metallurgy

12

N

530/13, 195/1.23

C12N 15/62 (2006.01) C07K 14/495 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/18 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2005120

ABSTRACT The invention relates to a chimeric transforming growth factor-.beta.1/.beta.2 comprising the amino acid sequence sub- stantially as depicted in FIG. 1 from about amino acid number 279 to about amino acid residue number 390; a cell containing a nucleotide coding sequence for chimeric transforming growth factor-.beta.1/.beta.2 substantially as depicted in FIG. 1 from about nucleotide number 1 to about nucleo- tide number 1170; and a method for producing chimeric trans- forming growth factor-.beta.1/.beta.2 comprising culturing a host cell containing a nucleotide coding sequence for chimeric transforming growth factor-.beta.1/.beta.2, substantially as depicted in FIG. 1 from about nucleotide number 836 to about nucleo- tide number 1170, under the control of a second nucleotide sequence that regulates gene expression so that a peptide or protein having chimeric transforming growth factor-.beta.1/.beta.2 activity is produced by the host cell; and recovering the chimeric transforming growth factor-.beta.1/.beta.2 from the culture. The chimeric gene product possesses TGF-.beta. biological activity in that it regulates cellular differentiation and proliferation and may be useful in treating cancer and pro- moting wound healing.

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