Tgf-.beta.1/.beta.2: novel chimeric transforming growth...

Details Tgf-.beta.1/.beta.2: novel chimeric transforming growth... Tgf-.beta.1/.beta.2: novel chimeric transforming growth...

A - Human Necessities

61

K

A61K 38/18 (2006.01) C07K 14/495 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2105877

2105877 9216228 PCTABS00016 The present invention relates to the production of large quantities of a novel chimeric TGF-.beta., termed TGF-.beta.1/.beta.2, by eucaryotic host cells transfected with recombinant DNA vectors containing the TGF-.beta.1/.beta.2 precursor coding sequence controlled by expresson regulatory elements. Simian TGF-.beta.1 cDNA (Sharples et al., 1987, DNA 6:239-244) was modified so that the nucleotides encoding amino acid residue numbers 9-13, 17, 19, 25 and 26 of the mature TGF-.beta.1 sequence were hanged to the nucleotides encoding the corresponding amino acids of the mature TGF-.beta.2 structure. Simian codon usage was maintained. The chimeric TGF-.beta.1/.beta.2 of the invention induces effects on the proliferation of vascular endothelial cells equivalent to those induced by TGF-.beta.1 (see Section 7., et seq.).

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