C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/17 (2006.01) C07K 14/715 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2729810
This disclosure provides a multi-target fusion protein composed of a TGF? antagonist domain and another binding domain antagonistic for a heterologous target (such as IL6, IL10, VEGF, TNF, HGF, TWEAK, IGF) or agonistic for a heterologous target (such as GITR). The multi-specific fusion protein may also include an intervening domain that separates the binding domains and allows for dimerization. This disclosure also provides polynucleotides encoding the multi-specific fusion proteins, compositions of the fusion proteins, and methods of using the multi-specific fusion proteins and compositions.
Cette invention concerne une protéine hybride multi-cible constituée dun domaine antagoniste du TGF-b et dun autre domaine de liaison antagoniste dune cible hétérologue (par exemple IL6, IL10, VEGF, TNF, HGF, TWEAK, IGF) ou agoniste dune cible hétérologue (par exemple GITR). La protéine hybride multi-spécifique peut également contenir un domaine interposé séparant les domaines de liaison et permettant la dimérisation. Cette invention concerne aussi des polynucléotides codant les protéines hybrides multi-spécifiques, des compositions constituées des protéines hybrides, et des procédés dutilisation des protéines hybrides multi-spécifiques et des compositions.
Baum Peter Robert
Lofquist Alan Keith
Misher Lynda
Thompson Peter Armstrong
Emergent Product Development Seattle Llc
Mbm Intellectual Property Law Llp
LandOfFree
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