Tgf-beta binding compositions

Details Tgf-beta binding compositions Tgf-beta binding compositions

C - Chemistry, Metallurgy

07

K

C07K 16/22 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2632799

The present invention provides very high affinity antibodies, or antigen- binding fragments thereof, that neutralize mature human TGF-.beta.l, TGF- .beta.2, and TGF-.beta.3. The antibodies of the invention are useful for treating cell proliferative disorders in a mammal.

La présente invention concerne des anticorps présentant une affinité très élevée, ou les fragments se liant aux antigènes de ces anticorps, neutralisant les TGF-.beta.l, TGF-.beta.2 et TGF-.beta.3 matures de l~homme. Les anticorps selon l~invention sont utiles pour le traitement des troubles liés à la prolifération cellulaire chez les mammifères.

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