Tgf.beta. rii receptor nucleic sequence, coded peptide, and...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/71 (2006.01) C12N 1/21 (2006.01) C12N 15/70 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2299678

The invention concerns a peptide comprising or consisting of a first peptide sequence of not more than 20 consecutive amino acids defined in a second peptide sequence coded by all or part of SEQ ID NO: 42 and different from SEQ ID NO: 1, said peptide being capable of being fixed on at least a class I major histocompatibility complex (MHC I) glycoprotein. The invention also concerns all nucleic sequence coding for such a peptide and the uses thereof in a vector, a host cell and in a pharmaceutical composition for diagnosing, preventing or treating in particular gastric or colon cancers.

L'invention concerne un peptide comprenant ou consistant en une première séquence peptidique d'au plus 20 acides aminés consécutifs définis dans une seconde séquence peptidique codée par tout ou partie de SEQ ID NO: 42 et différente de SEQ ID NO: 1, ledit peptide étant capable de se fixer sur au moins une glycoprotéine du complexe majeur d'histocompatibilité de classe I (CMH I); toute séquence nucléique codant pour un tel peptide et utilisations de celle-ci dans un vecteur, une cellule hôte et dans une composition pharmaceutique pour diagnostiquer, prévenir ou traiter notamment des cancers gastriques ou du colon.

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