C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) C07H 21/00 (2006.01) C07K 14/46 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2239126
The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here signalin-related genes, which are involved in signal transduction induced by members of the TGF.beta. superfamily. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
L'invention concerne la découverte du fait que les protéines codées par une famille de gènes de vertébrés, appelés ici gènes apparentés à signaline, sont impliquées dans la transduction de signal provoquée par des membres de la super-famille TGF.beta.. Elle concerne également des compositions et des procédés pouvant être utilisés, par exemple, pour générer et/ou conserver un groupement de différents tissus de vertébrés à la fois in vitro et in vivo.
Graff Jonathan M.
Jin Ping
Melton Douglas A.
Woolf Tod M.
Borden Ladner Gervais Llp
Curis Inc.
Ontogeny Inc.
President And Fellows Of Harvard College
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