Tgr5 modulators and methods of use thereof

Details Tgr5 modulators and methods of use thereof Tgr5 modulators and methods of use thereof

C - Chemistry, Metallurgy

07

J

C07J 9/00 (2006.01) A61K 31/575 (2006.01) A61P 1/16 (2006.01) C07J 31/00 (2006.01) C07J 41/00 (2006.01)

Patent

CA 2744189

The invention relates to compounds of Formula A: (A) or a salt, solvate, hydrate, or prodrug thereof. The compounds of Formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, liver disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.

L'invention concerne des composés de la formule A : (A) ou un sel, un solvate, un hydrate ou un promédicament de ces composés. Les composés de la formule A sont des modulateurs de TGR5 qui sutilisent dans le traitement de diverses maladies, comprenant les maladies métaboliques, les maladies inflammatoires, les maladies du foie, les maladies auto-immunes, les maladies cardiaques, les maladies du rein, le cancer et les maladies gastro-intestinales.

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