Tgr5 modulators and methods of use thereof

Details Tgr5 modulators and methods of use thereof Tgr5 modulators and methods of use thereof

C - Chemistry, Metallurgy

07

J

C07J 9/00 (2006.01) A61K 31/575 (2006.01) A61P 1/16 (2006.01) C07J 31/00 (2006.01) C07J 41/00 (2006.01)

Patent

CA 2676417

The invention relates to compounds of Formula A: (A) or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof. The compounds of Formula A are TGR5 modulators useful for the treatment of various diseases, including obesity, insulin sensitivity, inflammation, cholestasis, and bile desaturation.

L'invention concerne des composés de formule A : (A) ou un sel, un solvate, un hydrate ou un promédicament de ceux-ci acceptable du point de vue pharmaceutique. Les composés de formule A sont des modulateurs de TGR5 utiles pour le traitement de diverses maladies, parmi lesquelles l'obésité, une sensibilité à l'insuline, une inflammation, une cholestase et une désaturation de la bile.

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