A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61P 7/02 (2006.01)
Patent
CA 2718749
The present invention relates to a pharmaceutical composition comprising an inhibitor of stromal interaction molecule 1 (STIM1) or an inhibitor of STIM1 - regulated plasma membrane calcium channel activity, in particular an inhibitor of Oraii (also designated as CRACM1), and optionally a pharmaceutically active carrier, excipient or diluent. The invention further relates to an inhibitor of stromal interaction molecule 1(STIM1) or an inhibitor of ST I Ml -regulated plasma membrane calcium channel activity, in particular an inhibitor of Orai1 (also designated as CRACM1), for treating and/or preventing a disorder related to venous or arterial thrombus formation.
La présente invention porte sur une composition pharmaceutique comprenant un inhibiteur d'une molécule à interaction stromale 1 (STIM1) ou un inhibiteur d'activité de canal calcique de membrane de plasma régulée par STIM1, en particulier un inhibiteur de Orai1 (également appelé CRACM1), et éventuellement un support, excipient ou diluant pharmaceutiquement acceptable. L'invention porte en outre sur un inhibiteur d'une molécule à interaction stromale 1 (STIM1) ou sur un inhibiteur d'activité de canal calcique de membrane de plasma régulée par STIM1, en particulier un inhibiteur de Orai1 (également appelé CRACM1), pour traiter et/ou prévenir un trouble apparenté à la formation d'un thrombus veineux ou artériel.
Braun Attila
Kleinschnitz Christoph
Nieswandt Bernhard
Stoll Guido
Varga-Szabo David
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Csl Behring Gmbh
Julius-Maximilians Universitaet Wuerzburg
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