The citrate salt of 5, 8,...

Details The citrate salt of 5, 8,... The citrate salt of 5, 8,...

C - Chemistry, Metallurgy

07

D

C07D 471/08 (2006.01) A61K 31/498 (2006.01)

Patent

CA 2446988

The present invetion is directed to the citrate salt of 5, 8, 14- triazatetracyclo[10.3.1.02.11.04.9]-hexadeca-2(11),3,5,7,9-pentaene, formula 1, and pharmaceutical compositions thereof. The presetn invention is also directed to the various forms fo the citrate salt, particularly its hydrate and its anhydrous/nearly anyhydrous polmorph. The invention is also directed to processes for preparation of these citrate salt forms.

L'invention concerne le sel citrate de 5, 8, 14-triazatétracyclo[10.3.1.0<2,11>.0<4,9>]-hexadéca-2(11),3,5,7,9-pentaène, représenté par la formule (1) ci-après, y compris des compositions pharmaceutiques à base de ce sel. L'invention concerne également diverses formes de sel citrate, en particulier la forme hydrate et le polymorphe anhydre/quasi-anhydre correspondants. L'invention concerne en outre des procédés relatifs à l'élaboration des formes considérées.

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