The combination of a serotonin reuptake inhibitor and a...

A - Human Necessities – 61 – K

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A61K 45/06 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2536275

The present invention relates to the use of a compound, which is a serotonin reuptake inhibitor, and a compound, which is a GlyT-1 inhibitor for the preparation of a pharmaceutical composition for the treatment of depression, anxiety disorders and other affective disorders. In particular the present invention relates to treatment of depression, anxiety disorders and other affective disorders, such as generalized anxiety disorder, panic anxiety, obsessive compulsive disorder, acute stress disorder, post traumatic stress disorder and social anxiety disorder, eating disorders such as bulimia, anorexia and obesity, phobias, dysthymia, premenstrual syndrome, cognitive disorders, impulse control disorders, attention deficit hyperactivity disorder, drug abuse or any other disorder responsive to serotonin reuptake inhibitors. The present invention also relates to a pharmaceutical composition comprising a serotonin reuptake inhibitor, and a GlyT-1 inhibitor.

La présente invention concerne l'utilisation d'un composé inhibiteur du recaptage de la sérotonine et d'un composé inhibiteur du GlyT-1 pour l'élaboration d'une composition pharmaceutique destinée au traitement de la dépression, des troubles de l'anxiété, et d'autres troubles affectifs. L'invention concerne plus particulièrement le traitement de la dépression, des troubles de l'anxiété, et d'autres troubles affectifs tels que le trouble d'anxiété généralisée, l'anxiété panique, la névrose obsessionnelle, le trouble du stress aigu, le syndrome du stress post-traumatique, et le trouble de l'anxiété sociale, les troubles de l'alimentation tels que la boulimie, l'anorexie et l'obésité, les phobies, la dysthymie, le syndrome prémenstruel, les troubles cognitifs, le trouble du contrôle des impulsions, l'hyperactivité avec déficit de l'attention, les toxicomanies, et tous les autres troubles réagissant aux inhibiteurs du recaptage de la sérotonine. L'invention concerne également une composition pharmaceutique comprenant un inhibiteur du recaptage de la sérotonine, et un inhibiteur des GkyT-1.

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