The combination of a serotonin reuptake inhibitor and a...

A - Human Necessities – 61 – K

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A61K 31/135 (2006.01) A61K 31/343 (2006.01) A61K 31/454 (2006.01) A61K 45/06 (2006.01) A61P 25/18 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2549574

The invention relates to the use of a compound, which is a serotonin reuptake inhibitor, and another compound, which is a H3 receptor antagonist, inverse agonist or partial agonist for the preparation of a pharmaceutical composition for the treatment of depression, anxiety disorders and other affective disorders, such as generalized anxiety disorder, panic anxiety, obsessive compulsive disorder, acute stress disorder, post traumatic stress disorder and social anxiety disorder, eating disorders such as bulimia, anorexia and obesity, phobias, dysthymia, premenstrual syndrome, cognitive disorders, impulse control disorders, attention deficit hyperactivity disorder, drug abuse or any other disorder responsive to serotonin reuptake inhibitor.

L'invention concerne l'utilisation d'un composé, qui est un inhibiteur de réabsorption de la sérotonine, et un autre composé, qui est un antagoniste du récepteur H3, un agoniste inversé ou partiel pour la préparation d'une composition pharmaceutique permettant le traitement de la dépression, des troubles de l'anxiété et d'autres troubles affectifs, tels que le trouble de l'anxiété généralisé, la panique, les troubles compulsifs obsessionnels, le trouble du stress aigu, le trouble du stress post traumatique et le trouble de l'anxiété sociale, les troubles de l'alimentation, tels que la boulimie, l'anorexie et l'obésité, la phobie, la dysthymie, le syndrome prémenstruel, les troubles cognitifs, les troubles du contrôle des pulsions, les troubles de l'hyperactivité du déficit d'attention, l'abus de médicaments ou tout autre trouble sensible à l'inhibiteur de réabsorption de la sérotonine.

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