The combination of antimicrobial agents and bacterial...

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/00 (2006.01) A61L 29/00 (2006.01) A61L 29/08 (2006.01) A61L 29/16 (2006.01)

Patent

CA 2411944

This invention relates to a method for coating a medical device comprising the steps of applying to at least a portion of the surface of said medical device, an antimicrobial coating layer and a non-pathogenic bacterial coating layer, wherein the antimicrobial and non-pathogenic bacterial coating layers inhibit the growth of pathogenic bacterial and fungal organisms. The non-pathogenic bacterium used in the bacterial coating layer is resistant to the antimicrobial agent. Furthermore, the non-pathogenic bacterium layer includes at least one of the following: viable whole cells, non-viable whole cells, or cellular structures or extracts. The antimicrobial agent and non-pathogenic bacterium are used to develop a kit comprising these compositions in one container or in separate containers. The kit is used to coat a catheter prior to implantation in a mammal.

Cette invention concerne une méthode d'enduction d'un dispositif médical, qui consiste à appliquer à au moins une partie de la surface dudit dispositif médical une couche de revêtement antimicrobienne et une couche de revêtement bactérienne non pathogène, lesquelles couches inhibent le développement d'organismes bactériens et fongiques pathogènes. La bactérie non pathogène utilisée dans la couche de revêtement bactérienne est résistante à l'agent antimicrobien. De plus la couche bactérienne non pathogène comprend au moins des cellules entières viables, ou des cellules entières non viables, ou des structures ou extraits cellulaires. L'agent antimicrobien et la bactérie non pathogène sont utilisés pour mettre au point une trousse comprenant ces compositions dans un seul récipient ou dans des récipients distincts. Cette trousse est utilisée pour enduire un cathéter préalablement à son implantation chez un mammifère.

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