C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 38/22 (2006.01) A61K 38/26 (2006.01) A61P 3/10 (2006.01) C07K 14/595 (2006.01) C07K 14/605 (2006.01)
Patent
CA 2554458
The invention relates to compositions, conjugates, and methods for the prevention and/or treatment of a condition and/or disease comprising a therapeutically effective amount of a GLP-1 agonist and a gastrin compound. The combination of a GLP-1 agonist and a gastrin compound provides beneficial effects, in particular sustained beneficial effects, in the prevention and/or treatment of conditions and/or diseases for which either a GLP-1 agonist or a gastrin compound have been demonstrated to have a therapeutic effect, including but not limited to diabetes, hypertension, chronic heart failure, fluid retentive states, obesity, metabolic syndrome and related diseases and disorders. Combinations of a GLP-1 agonist and a gastrin compound can be selected to provide unexpectedly additive effects or synergistic effects.
La présente invention concerne des compositions, des conjugués et des procédés convenant à la prévention et/ou au traitement d'un état et/ou d'une affection, comprenant un agoniste de GLP-1 en quantité thérapeutiquement efficace, associé à un composé gastrinique. L'association de l'agoniste de GLP-1 et d'un composé gastrinique s'avère bénéfique, et notamment de façon soutenue, pour la prévention et/ou le traitement d'états et/ou d'affections pour lesquels un agoniste de GLP-1 ou un composé gastrinique ont fait preuve d'un effet thérapeutique, ce qui concerne notamment le diabète, l'hypertension, les cardiopathie chroniques, la rétention d'eau, l'obésité, le syndrome métabolique et des troubles et affections s'y rapportant. L'association d'un agoniste de GLP-1 et d'un composé gastrinique peut être choisie pour procurer de façon inattendue des effets cumulatifs ou des effets de synergie.
Cruz Antonio
Hew Yin
Pastrak Aleksandra
Gowling Lafleur Henderson Llp
Waratah Pharmaceuticals Inc.
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