The elucidation and synthesis of antineoplastic tetrapeptide...

Details The elucidation and synthesis of antineoplastic tetrapeptide... The elucidation and synthesis of antineoplastic tetrapeptide...

C - Chemistry, Metallurgy

07

K

C07K 5/027 (2006.01) A61K 38/07 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2110556

Dolastatin 10, a linear pentapeptide, has shown potent antineoplastic activity profiles against various experimental cancer systems. The design and synthesis of structural modifications of dolastatin 10 having significant antineoplastic activity against human cancer cell lines has been accomplished. Members of this group have demonstrated significant antineoplastic activity against selected human cancer cell lines. Especially: Ovarian OVCAR-3; Central Nervous System ("CNS") SF295; Renal A498; Lung NCI460; Colon KM20L2 and Melanoma SK-MEL-3.

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