C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) C07K 7/08 (2006.01) C07K 14/11 (2006.01) C07K 14/395 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C07K 19/00 (2006.01) C12N 9/12 (2006.01) C12N 9/96 (2006.01) C12N 15/31 (2006.01) C12N 15/62 (2006.01) C12Q 1/48 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2219958
-83- The present invention relates generally to signal transduction through G-protein-coupled receptors and more particularly to the interaction between the .beta. subunit of the heterotrimeric G-protein and the Ste20p/PAK family of protein kinases. More particularly, the invention is directed to the identification of the G-protein .beta. subunit interaction domain of Ste20p/PAK family of protein kinases, the Ste20p/PAK interaction domain of G-protein .beta. subunit, to antibodies specific for these interacting domains, the nucleic acid molecules encoding same, to assays, expression vectors, indicator cells, strains, methods and agents which make use of this Ste20p/PAK - G .beta. interaction.
Leberer Ekkehard
Leeuw Thomas
Thomas David Y.
Whiteway Malcolm
Anderson J. Wayne
Leberer Ekkehard
Leeuw Thomas
National Research Council Of Canada
Thomas David Y.
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