The il-1 gene cluster and associated inflammatory...

Details The il-1 gene cluster and associated inflammatory... The il-1 gene cluster and associated inflammatory...

C - Chemistry, Metallurgy

12

N

C12N 15/25 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2473641

The invention provides methods and compositions relating to identification and use of genetic information from the IL-1 gene cluster-including the structure and organization of novel IL-1 like genes found within the IL-1 locus as well as polymorphisms and associated haplotypes within these genes. The invention thereby expands the repertoire of useful genetic information available from the IL-1 locus - which contains the previously-identified IL-1.alpha., IL- 1.beta. and IL-1RN genes, for predicting IL-1 associated phenotypes (e.g. increased or decreased risks of inflammatory disease) and for treating IL-1 haplotype associated inflammatory phenotypes.

L'invention concerne des méthodes et des compositions associées à l'identification et à l'utilisation d'informations génétiques provenant de la batterie de gènes d'IL-1, telles que des informations de structure et d'organisation de nouveaux gènes de type IL-1 isolés dans le locus d'IL-1, ainsi que des polymorphismes et des haplotypes associés compris dans ces gènes. L'invention permet ainsi d'étendre le répertoire des informations génétiques utiles disponibles provenant du locus d'IL-1, lequel contient les gènes d'IL-1.alpha., d'IL-1.beta. et d'IL-RN déjà identifiés, d'où la possibilité de prédire les phénotypes associés à IL-1 (par ex., les risques accrus ou réduits de développer une maladie inflammatoire), et de traiter les phénotypes inflammatoires associés aux haplotypes d'IL-1.

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