C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2569698
This invention relates to the detection of increased expression from the HoxB13 (homeobox B13) gene as indicative of an invasive or metastatic cancer phenotype. The invention provides methods of detecting the level c expression from the HoxB13 gene, optionally in combination with nodal status, as an indicator of the invasive or metastatic phenotype as well as increased cellular migration and/or mobility. The invention also provides for the measurement of expression from the HoxB13 gene to assist in the determination of patient prognosis as well as clinical diagnosis and treatment.
L'invention concerne la détection d'une augmentation de l'expression du gène HoxB13 (homeobox B13) comme indicateur d'un phénotype invasif ou métastatique du cancer. L'invention concerne des procédés de détection du niveau d'expression du gène HoxB13, éventuellement en association avec l'état nodal, comme indicateur du phénotype invasif ou métastatique ainsi que comme migration et/ou mobilité cellulaire accrue. L'invention concerne également la mesure de l'expression du gène HoxB13 pour aider à déterminer le pronostic du patient ainsi que le diagnostic et le traitement du patient.
Erlander Mark G.
Ma Xiao-Jun
Sgroi Dennis C.
Aviaradx Inc.
Smart & Biggar
The General Hospital Corporation
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