The induction of antibiotic peptides by lait (scd14) protein

Details The induction of antibiotic peptides by lait (scd14) protein The induction of antibiotic peptides by lait (scd14) protein

A - Human Necessities

61

K

A61K 38/17 (2006.01) A01K 67/027 (2006.01) A23L 1/305 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 15/00 (2006.01) G01N 33/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2328134

A method of ameliorating the symptoms of sepsis comprising directly exposing epithelial cells of a mammal in need thereof to soluble CD14, or active variants thereof. A method of obtaining CD14 from a stock solution containing protein of a mammary secretion is described. A method of directly activating B cells using a soluble polypeptide having the amino acid sequence selected from the group consisting of leu-leu-leu-leu-leu-leu-pro-ser, leu-leu-leu-leu-leu- leu-pro-leu; and leu-leu-leu-leu-leu-leu-val-his, and which is specifically recognized by the monoclonal antibody 3C10 and which activates B cells is described. Bovine CD14 genomic DNA is described.

L'invention concerne une méthode d'atténuation des symptômes de la septicémie, qui consiste à exposer directement les cellules épithéliales d'un mammifère en ayant besoin, à des CD14 solubles, ou des variantes actives de celles-ci. Une méthode de production de CD14 à partir d'une solution contenant une solution-mère de départ, d'une sécrétion mammalienne, est décrite. Est également décrite une méthode d'activation directe des cellules B au moyen d'un polypeptide soluble possédant la séquence d'acides aminés choisie dans le groupe constitué de leu-leu-leu-leu-leu-leu-pro-ser; leu-leu-leu-leu-leu-leu-pro-leu; et leu-leu-leu-leu-leu-leu-val-his, et qui est reconnue spécifiquement par l'anticorps monoclonal 3C10 et qui active les cellules B. L'ADN génomique de CD14 bovin est décrit.

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