The isolation and production of catalytic antibodies using...

Details The isolation and production of catalytic antibodies using... The isolation and production of catalytic antibodies using...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/44 (2006.01) C07K 16/46 (2006.01)

Patent

CA 2186469

Disclosed and claimed are methods for producing catalytic antibodies, including human catalytic antibodies from bacteriophage. The methods require the cloning, selection, screening, and isolation of catalytic antibodies. Also disclosed and claimed are the products themselves, the catalytic antibodies, made from the phage technology. In addition, catalytic antibodies produced from the phage technology and useful in prodrug activation are disclosed and claimed. And finally, the invention also understands the production of catalytic antibodies to phosphonates.

On décrit et on revendique des procédés pour produire des anticorps catalytiques, en particulier des anticoprs catalytiques humains, à partir de bactériophages. Les procédés consistent à cloner, sélectionner, trier et isoler les anticorps catalytiques. Egalement, on décrit et on revendique les produits eux-mêmes, les anticorps catalytiques, préparés par cette technolgie faisant appel à des phages. En plus, on décrit et on revendique les anticorps catalytiques produits par la technologie faisant appel à des phages et qui sont utiles pour l'activation de précurseurs de médicaments. Finalement, l'invention concerne également la production d'anticorps à action catalytique vis-à-vis des phosphonates.

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