C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) A61K 31/395 (2006.01) A61K 31/7105 (2006.01) A61K 31/711 (2006.01) A61K 31/7115 (2006.01) A61K 31/712 (2006.01) A61K 31/7125 (2006.01) A61P 35/00 (2006.01) C07H 21/02 (2006.01) C07K 16/40 (2006.01)
Patent
CA 2541438
Modulation of Hyaluronan (HA) synthesis and degradation is disclosed by compounds and compositions that are capable of reducing the level of hyaluronan synthase (HAS) or hyaluronidase (HYAL) or the function or activity of HAS or HYAL. The compounds and compositions can also inhibit the expression of genetic material encoding these enzymes. The compounds and compositions comprise nucleic acid molecules and interactive molecules such as antibodies, small molecule inhibitors and substrate analogs of HAS and HYAL. The compounds and compositions are useful in the prophylaxis and/or treatment of inflammatory disorders including hyperproliferative conditions, such as but not limited to, cancer and psoriasis.
La présente invention concerne la modulation de la synthèse et la dégradation Hyaluronan (HA) par des composés et des compositions capables de réduire le niveau d'hyaluronan synthase (HAS) ou d'hyaluronidase (HYAL) ou la fonction ou l'activité de HAS ou de HYAL. Ces composés et ces compositions peuvent aussi inhiber l'expression de matériaux génétiques codants pour ces enzymes. Ces composés et ces compositions comprennent des molécules d'acides nucléiques et des molécules interactives telles que des anticorps, des inhibiteurs de petites molécules et des analogues de substrat de HAS et de HYAL. Ces composés et ces compositions conviennent pour la prophylaxie et/ou le traitement de troubles inflammatoires notamment des états hyperprolifératifs, tels que notamment, le cancer et le psoriasis.
Brown Tracey Jean
Brownlee Gary Russell
Alchemia Oncology Pty Limited
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Meditech Research Limited
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