C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/18 (2006.01) A61P 1/16 (2006.01) C07K 14/475 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2440775
The present invention relates to variants of the NK1 fragment of the polypeptide growth factor HGF/SF which act as agonists of the MET receptor and their use. The agonists comprise at least one substitution at positions equivalent to 132, 134, 170 and 181 of full length HGF/SF and these substitutions provide a variant which shows scatter factor activity and induces DNA synthesis. In vivo the variants provide protection from liver damage in a model of acute liver failure.
L'invention porte sur des variants du fragment NK1 du facteur de croissance polypeptidique HGF/SF agissant comme agonistes du récepteur MET ainsi que leur utilisation. Les agonistes comprennent au moins une substitution à des positions équivalentes à 132, 134, 170 et 181 de la longueur totale de HGF/SF et ces substitutions offrent un variant qui fait preuve d'une activité de facteur de diffusion et induit la synthèse d'ADN. Les variants in vivo assurent une protection contre des lésions du foie dans un modèle d'insuffisance aiguë hépatique.
Blundell Thomas Leon
Chirgadze Dimitry Yurievich
Gherardi Ermanno
Lietha Daniel
Cambridge University Technical Services Limited
Medical Research Council
Smart & Biggar
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