The novel adipocytokine visfatin/pbef1 is an apoptosis...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2689131

The present invention relates to the use of monocyte markers for diagnostic, prognostic or theranostic applications during diseases and syndromes caused by HIV infection. More specifically, it relates to a method, comprising isolation of monocytes and determining gene expression, preferably PBEF1 gene expression. Said method is useful to determine the evolution of the disease or can be used to evaluate the efficacy of a treatment.

La présente invention porte sur l'utilisation de marqueurs de monocytes pour des applications de diagnostic, de pronostique ou de thérapie pendant des maladies et des syndromes provoqués par une infection par le VIH. Plus spécifiquement, la présente invention porte sur un procédé, comprenant l'isolement de monocytes et la détermination d'une expression de gène, de préférence une expression du gène PBEF1. Ledit procédé est utile pour déterminer l'évolution de la maladie ou peut être utilisé pour évaluer l'efficacité d'un traitement.

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