The ob receptor and methods of diagnosing and treating weight

Details The ob receptor and methods of diagnosing and treating weight The ob receptor and methods of diagnosing and treating weight

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 38/22 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 14/715 (2006.01) C07K 14/72 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 9/12 (2006.01) C12N 15/62 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2238569

The present invention relates to the discovery, identification and characterization of nucleotides that encode Ob receptor (ObR), a receptor protein that participates in mammalian body weight regulation. The invention encompasses <u>obR</u> nucleotides, host cell expression systems, ObR proteins, fusion proteins, polypeptides and peptides, antibodies to the receptor, transgenic animals that express an <u>obR</u> transgene, or recombinant knock-out animals that do not express the ObR, antagonists and agonists of the receptor, and other compounds that modulate <u>obR</u> gene expression or ObR activity that can be used for diagnosis, drug screening, clinical trial monitoring, and/or the treatment of body weight disorders, including but not limited to obesity, cachexia and anorexia.

Cette invention concerne la découverte, l'identification et la caractérisation de nucléotides qui codent le récepteur Ob (ObR), une protéine de récepteur qui participe à la régulation de la masse corporelle chez les mammifères. Cette invention concerne des nucléotides <u>obR</u>, des systèmes d'expression de cellule hôte, des protéines ObR, des protéines de fusion, des polypeptides et des peptides, des anticorps dirigés contre le récepteur, des animaux transgéniques qui expriment un transgène <u>obR</u> ou des animaux morts produits par recombinaison qui n'expriment pas ObR, des antagonistes et des agonistes du récepteur, et d'autres composés qui modulent l'expression du gène <u>obR</u> ou l'activité de ObR et qu'on peut utiliser pour le diagnostic, la recherche de médicaments, la surveillance des essais cliniques et/ou le traitement des dérèglements de la masse corporelle incluant entre autres l'obésité, la cachexie et l'anorexie.

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