The preparation of colloidal aqueous solutions of active...

Details The preparation of colloidal aqueous solutions of active... The preparation of colloidal aqueous solutions of active...

C - Chemistry, Metallurgy

11

C

C11C 3/04 (2006.01) A61K 9/10 (2006.01) A61K 47/14 (2006.01) A61K 47/24 (2006.01) A61K 47/44 (2006.01) B01J 13/00 (2006.01) C07C 69/40 (2006.01)

Patent

CA 2153893

A method for forming a solution of only slightly soluble active substances is described, comprising the following steps: a) the active substance is dissolved, together with a phospholipid and a water-soluble lipid, in an organic solvent; 2) the solution thus obtained is reduced in volume; 3) die residue is taken up in a strongly acid buffer solution and stirred at elevated temperature until a colloidal solution forms; 4) the colloidal solution is cooled its pH adjusted to a value of 6 to 7 and the solution sterilized. Particularly suitable for use in this method are lipids of formula (I) In which m, a, b, z and y are as defined in the description.

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