C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 263/42 (2006.01) C07C 227/32 (2006.01)
Patent
CA 2284591
Allylic electrophiles are alkylated with oxazolones in the presence of a base and catalytic quantities of a transition metal complex incorporating a chiral phosphine ligand, to yield 4,4-disubstituted-5(4H)-oxazolones. These precursors may be subsequently transformed either synthetically or enzymatically to yield enantiomerically enriched .alpha.,.alpha.-disubstituted amino acids.
L'invention concerne des électrophiles allyliques qui sont alcoylés avec des oxazolones en présence d'une base et de quantités catalytiques d'un complexe de métal de transition contenant un ligand de phosphine chirale, pour produire des oxazolones 4,4-disubstitués-5(4H). Ces précurseurs peuvent être ensuite transformés de manière synthétique ou enzymatique pour produire des acides aminés disubstitués .alpha.,.alpha. riches en énantiomères.
Piquer Javier Ariza
Trost Barry M.
Borden Ladner Gervais Llp
The Board Of Trustees Of The Leland Stanford Junior University
LandOfFree
The preparation of enantiomerically enriched oxazolones and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with The preparation of enantiomerically enriched oxazolones and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and The preparation of enantiomerically enriched oxazolones and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1579631