The preparation of enantiomerically enriched oxazolones and...

Details The preparation of enantiomerically enriched oxazolones and... The preparation of enantiomerically enriched oxazolones and...

C - Chemistry, Metallurgy

07

D

C07D 263/42 (2006.01) C07C 227/32 (2006.01)

Patent

CA 2284591

Allylic electrophiles are alkylated with oxazolones in the presence of a base and catalytic quantities of a transition metal complex incorporating a chiral phosphine ligand, to yield 4,4-disubstituted-5(4H)-oxazolones. These precursors may be subsequently transformed either synthetically or enzymatically to yield enantiomerically enriched .alpha.,.alpha.-disubstituted amino acids.

L'invention concerne des électrophiles allyliques qui sont alcoylés avec des oxazolones en présence d'une base et de quantités catalytiques d'un complexe de métal de transition contenant un ligand de phosphine chirale, pour produire des oxazolones 4,4-disubstitués-5(4H). Ces précurseurs peuvent être ensuite transformés de manière synthétique ou enzymatique pour produire des acides aminés disubstitués .alpha.,.alpha. riches en énantiomères.

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