The preparation of n-z-protected n-methylated amino acids

Details The preparation of n-z-protected n-methylated amino acids The preparation of n-z-protected n-methylated amino acids

C - Chemistry, Metallurgy

07

C

C07C 271/22 (2006.01) C07C 227/18 (2006.01) C07C 229/02 (2006.01) C07C 269/06 (2006.01) C07C 319/20 (2006.01) C07C 323/59 (2006.01) C07C 323/60 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2190656

A process for producing N-protected N-alkylated amino acids of formula (I) is described in which the components have the meaning given in the description. In the process, to a compound of formula (II) is added a solution of potassium- tert.-butanolate in a non-proteinic organic solvent and then a C1-2-alkyl halide is added.

L'invention concerne un procédé de préparation d'acides aminés N-alkylés à protection N de la formule (I), dans laquelle les substituants correspondent à la notation mentionnée dans la description. Ce procédé consiste à mélanger un composé de la formule (II) avec une solution de tert -butalonate de potassium dans un solvant organique non protéique et à ajouter ensuite un halogénure d'alkyle C¿1-2?.

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