The preparation of nalbuphine having low levels of beta-epimer

Details The preparation of nalbuphine having low levels of beta-epimer The preparation of nalbuphine having low levels of beta-epimer

C - Chemistry, Metallurgy

07

D

C07D 489/08 (2006.01)

Patent

CA 2191843

A process is described for the synthesis of nalbuphine. The process results in a product having very low levels of the undesirable .beta.-epimer. The process is a five-step synthesis that begins with a compound such as an N,O3-bis(alkoxycarbonyl)-14-hydroxynormorphinone.

L'invention concerne un procédé de synthèse de la nalbuphine qui permet d'obtenir un produit à très faibles taux de beta -épimère indésirable. Le procédé consiste en une synthèse en cinq étapes à partir d'un composé tel que la N,0<3>-bis(alcoxycarbonyl)-14-hydroxynormorphinone.

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