The preparation of stable injectable .beta.-carotene...

A - Human Necessities – 61 – K

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A61K 31/015 (2006.01) A61K 9/107 (2006.01) A61K 31/07 (2006.01) A61K 47/14 (2006.01)

Patent

CA 2051978

O.Z. 0050/41928 Abstract of the disclosure: A process for the continuous preparation of .beta.-carotene solubilizates by briefly heating .beta.-carotene together with an emulsifier to give a homogeneous solution, rapidly cooling the latter to below 100°C by adding water, and subsequently adjusting to the required final concentration of .beta.-carotene, comprises pumping a suspension, which has been preheated to from 20 to 80°C, of from 1 to 40 % by weight of .beta.-carotene in an emulsifier through a heating coil located in a heat- transfer oil, where the solubilization mixture is at from 120 to 180°C and the residence time is from 10 to 300 seconds, and subjecting the homogeneous solution to turbulent mixing in a mixing chamber with an amount of water at from 10 to 80°C to result in a solubilizate which contains from 0.5 to 6 % by weight of .beta.-carotene and is, if necessary, diluted to the required final concentration.

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