The production of hemoglobin having a .delta.-like globin

Details The production of hemoglobin having a .delta.-like globin The production of hemoglobin having a .delta.-like globin

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 35/14 (2006.01) A61K 38/17 (2006.01) A61K 38/42 (2006.01) C07K 14/805 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2192066

The present invention concerns a method and compositions of matter useful for the method of making, in transgenic animals, a human hemoglobin that is more stable and more readily purified from the endogenous hemoglobins of the transgenic animal than hemoglobin A. The hemoglobins produced by the invention include hemoglobin A2, which is an .alpha.2.delta.2 tetramer, as well as other hemoglobins having similar properties to hemoglobin A2 and have .beta./.delta. chimeric globins. The specification discloses a chimeric gene, encoding a human .delta.-globin that is expressed in trangenic animals at levels approximating the level of expression of the .alpha. or .beta. globin.

L'invention concerne un procédé et des compositions associés permettant de produire, chez des animaux transgéniques, une hémoglobine humaine qui est plus stable et plus facilement débarrassée des hémoglobines endogènes de l'animal transgénique que l'hémoglobine A. Les hémoglobines produites selon l'invention comprennent l'hémoglobine A¿2?, qui est un tétramère .alpha.¿2?.delta.¿2?, ainsi que d'autres hémoglobines ayant des propriétés similaires à celle de l'hémoglobine A¿2? et contiennent des globines chimères .beta./.delta.. Il est décrit un gène chimère codant une .delta.-globine humaine qui est exprimée dans des animaux transgéniques à des niveaux proches du niveau d'expression de l'.alpha.-globine ou de la .beta.-globine.

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